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'Lipid Rescue Resuscitation' is a term coined by Guy Weinberg MD denoting the use of intravenous lipid
emulsion (ILE) preparations as antidote. Since initial discovery a decade ago ILE have been reported to reverse central nervous
system, and cardiotoxicity from overdose with lipophilic local anaesthetics. More recently ILE has been reported to ameliorate
neurologic and cardiovascular manifestations of non local anaesthetic lipophilic-drug poisonings in animal models
and anecdotal human cases.
Systemic evaluation
of ILE in human cases of overdose is however limited by ethical constraints associated with the infrequent and catastrophic
nature of such presentations. In the absence of randomized clinical trials of ILE, a prospective registry of ILE use is required
to collate clinical experience of efficacy, and adverse events, associated with ILE use.
The LIPAEMIC (Lipid Injection for the
Purpose of Antidotal Effect in lipophilic
Medicine IntoxiCation) Study Group
is an international collaborative of clinician investigators formed with the aim of compiling a prospective dataset of uses
of ILE as antidote. LIPID REGISTRY is a project
of the LIPAEMIC Study Group.
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A companion website to LipidRescue
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